Perturbation-response genes reveal signaling footprints in cancer gene expression

Aberrant cell signaling can cause cancer and other diseases and is a focal point of drug research. A common approach is to infer signaling activity of pathways from gene expression. However, mapping gene expression to pathway components disregards the effect of post-translational modifications, and...

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Detalles Bibliográficos
Autores principales: Schubert, Michael, Klinger, Bertram, Klünemann, Martina, Sieber, Anja, Uhlitz, Florian, Sauer, Sascha, Garnett, Mathew J., Blüthgen, Nils, Saez-Rodriguez, Julio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5750219/
https://www.ncbi.nlm.nih.gov/pubmed/29295995
http://dx.doi.org/10.1038/s41467-017-02391-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5750219/
https://www.ncbi.nlm.nih.gov/pubmed/29295995
http://dx.doi.org/10.1038/s41467-017-02391-6

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