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Circulating exosomes suppress the induction of regulatory T cells via let-7i in multiple sclerosis
Multiple sclerosis (MS) is a T cell-mediated autoimmune disease of the central nervous system. Foxp3(+) regulatory T (Treg) cells are reduced in frequency and dysfunctional in patients with MS, but the underlying mechanisms of this deficiency are unclear. Here, we show that induction of human IFN-γ(...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5750223/ https://www.ncbi.nlm.nih.gov/pubmed/29295981 http://dx.doi.org/10.1038/s41467-017-02406-2 |