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Circulating exosomes suppress the induction of regulatory T cells via let-7i in multiple sclerosis

Multiple sclerosis (MS) is a T cell-mediated autoimmune disease of the central nervous system. Foxp3(+) regulatory T (Treg) cells are reduced in frequency and dysfunctional in patients with MS, but the underlying mechanisms of this deficiency are unclear. Here, we show that induction of human IFN-γ(...

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Detalles Bibliográficos
Autores principales:	Kimura, Kimitoshi, Hohjoh, Hirohiko, Fukuoka, Masashi, Sato, Wakiro, Oki, Shinji, Tomi, Chiharu, Yamaguchi, Hiromi, Kondo, Takayuki, Takahashi, Ryosuke, Yamamura, Takashi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5750223/ https://www.ncbi.nlm.nih.gov/pubmed/29295981 http://dx.doi.org/10.1038/s41467-017-02406-2

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