A Single Amino Acid Change in the Marburg Virus Glycoprotein Arises during Serial Cell Culture Passages and Attenuates the Virus in a Macaque Model of Disease

Marburg virus (MARV) causes disease with high case fatality rates, and there are no approved vaccines or therapies. Licensing of MARV countermeasures will likely require approval via the FDA’s Animal Efficacy Rule, which requires well-characterized animal models that recapitulate human disease. This...

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Detalles Bibliográficos
Autores principales: Alfson, Kendra J., Avena, Laura E., Delgado, Jenny, Beadles, Michael W., Patterson, Jean L., Carrion, Ricardo, Griffiths, Anthony
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5750385/
https://www.ncbi.nlm.nih.gov/pubmed/29299527
http://dx.doi.org/10.1128/mSphere.00401-17

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5750385/
https://www.ncbi.nlm.nih.gov/pubmed/29299527
http://dx.doi.org/10.1128/mSphere.00401-17

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