Stability of the Influenza Virus Hemagglutinin Protein Correlates with Evolutionary Dynamics

Protein thermodynamics are an integral determinant of viral fitness and one of the major drivers of protein evolution. Mutations in the influenza A virus (IAV) hemagglutinin (HA) protein can eliminate neutralizing antibody binding to mediate escape from preexisting antiviral immunity. Prior research...

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Detalles Bibliográficos
Autores principales: Klein, Eili Y., Blumenkrantz, Deena, Serohijos, Adrian, Shakhnovich, Eugene, Choi, Jeong-Mo, Rodrigues, João V., Smith, Brendan D., Lane, Andrew P., Feldman, Andrew, Pekosz, Andrew
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5750392/
https://www.ncbi.nlm.nih.gov/pubmed/29299534
http://dx.doi.org/10.1128/mSphereDirect.00554-17

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5750392/
https://www.ncbi.nlm.nih.gov/pubmed/29299534
http://dx.doi.org/10.1128/mSphereDirect.00554-17

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