In Vivo siRNA Delivery and Rebound of Renal LRP2 in Mice

siRNA stabilized for in vivo applications is filtered and reabsorbed in the renal proximal tubule (PT), reducing mRNA expression transiently. Prior siRNA efforts have successfully prevented upregulation of mRNA in response to injury. We proposed reducing constitutive gene and protein expression of L...

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Detalles Bibliográficos
Autores principales: Eadon, Michael T., Cheng, Ying-Hua, Hato, Takashi, Benson, Eric A., Ipe, Joseph, Collins, Kimberly S., De Luca, Thomas, El-Achkar, Tarek M., Bacallao, Robert L., Skaar, Todd C., Dagher, Pierre C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5750491/
https://www.ncbi.nlm.nih.gov/pubmed/29410918
http://dx.doi.org/10.1155/2017/4070793

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5750491/
https://www.ncbi.nlm.nih.gov/pubmed/29410918
http://dx.doi.org/10.1155/2017/4070793

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