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The Role of PXR Genotype and Transporter Expression in the Placental Transport of Lopinavir in Mice
Lopinavir (LPV), an antiretroviral protease inhibitor frequently prescribed in HIV-positive pregnancies, is a substrate of Abcb1 and Abcc2. As differences in placental expression of these transporters were seen in Pregnane X Receptor (PXR) −/− mice, we examined the impact of placental transporter ex...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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MDPI
2017
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5750655/ https://www.ncbi.nlm.nih.gov/pubmed/29064386 http://dx.doi.org/10.3390/pharmaceutics9040049 |