Volasertib Enhances Sensitivity to TRAIL in Renal Carcinoma Caki Cells through Downregulation of c-FLIP Expression

Polo-like kinase 1 (PLK1) plays major roles in cell cycle control and DNA damage response. Therefore, PLK1 has been investigated as a target for cancer therapy. Volasertib is the second-in class dihydropteridinone derivate that is a specific PLK1 inhibitor. In this study, we examined that combining...

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Detalles Bibliográficos
Autores principales: Jeon, Mi-Yeon, Min, Kyoung-jin, Woo, Seon Min, Seo, Seung Un, Kim, Shin, Park, Jong-Wook, Kwon, Taeg Kyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5751171/
https://www.ncbi.nlm.nih.gov/pubmed/29186071
http://dx.doi.org/10.3390/ijms18122568

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5751171/
https://www.ncbi.nlm.nih.gov/pubmed/29186071
http://dx.doi.org/10.3390/ijms18122568

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