Rapid Non-Enzymatic Glycation of the Insulin Receptor under Hyperglycemic Conditions Inhibits Insulin Binding In Vitro: Implications for Insulin Resistance

The causes of insulin resistance are not well-understood in either type 1 or type 2 diabetes. Insulin (INS) is known to undergo rapid non-enzymatic covalent conjugation to glucose or other sugars (glycation). Because the insulin receptor (IR) has INS-like regions associated with both glucose and INS...

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Detalles Bibliográficos
Autores principales: Rhinesmith, Tyler, Turkette, Thomas, Root-Bernstein, Robert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5751205/
https://www.ncbi.nlm.nih.gov/pubmed/29207492
http://dx.doi.org/10.3390/ijms18122602

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5751205/
https://www.ncbi.nlm.nih.gov/pubmed/29207492
http://dx.doi.org/10.3390/ijms18122602

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