Frequency-Dependent Multi-Well Cardiotoxicity Screening Enabled by Optogenetic Stimulation

Side effects on cardiac ion channels causing lethal arrhythmias are one major reason for drug withdrawals from the market. Field potential (FP) recording from cardiomyocytes, is a well-suited tool to assess such cardiotoxic effects of drug candidates in preclinical drug development, but it is curren...

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Detalles Bibliográficos
Autores principales: Rehnelt, Susanne, Malan, Daniela, Juhasz, Krisztina, Wolters, Benjamin, Doerr, Leo, Beckler, Matthias, Kettenhofen, Ralf, Bohlen, Heribert, Bruegmann, Tobias, Sasse, Philipp
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5751237/
https://www.ncbi.nlm.nih.gov/pubmed/29211031
http://dx.doi.org/10.3390/ijms18122634

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5751237/
https://www.ncbi.nlm.nih.gov/pubmed/29211031
http://dx.doi.org/10.3390/ijms18122634

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