Pharmacophore anchor models of flaviviral NS3 proteases lead to drug repurposing for DENV infection

BACKGROUND: Viruses of the flaviviridae family are responsible for some of the major infectious viral diseases around the world and there is an urgent need for drug development for these diseases. Most of the virtual screening methods in flaviviral drug discovery suffer from a low hit rate, strain-s...

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Detalles Bibliográficos
Autores principales: Pathak, Nikhil, Lai, Mei-Ling, Chen, Wen-Yu, Hsieh, Betty-Wu, Yu, Guann-Yi, Yang, Jinn-Moon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5751397/
https://www.ncbi.nlm.nih.gov/pubmed/29297305
http://dx.doi.org/10.1186/s12859-017-1957-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5751397/
https://www.ncbi.nlm.nih.gov/pubmed/29297305
http://dx.doi.org/10.1186/s12859-017-1957-5

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