Generation of megabase-scale deletions, inversions and duplications involving the Contactin-6 gene in mice by CRISPR/Cas9 technology

BACKGROUND: Copy Number Variation (CNV) of the human CNTN6 gene (encoding the contactin-6 protein), caused by deletions or duplications, is responsible for severe neurodevelopmental impairments, often in combination with facial dysmorphias. Conversely, deleterious point mutations of this gene do not...

Descripción completa

Detalles Bibliográficos
Autores principales: Korablev, Alexei N., Serova, Irina A., Serov, Oleg L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5751523/
https://www.ncbi.nlm.nih.gov/pubmed/29297312
http://dx.doi.org/10.1186/s12863-017-0582-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5751523/
https://www.ncbi.nlm.nih.gov/pubmed/29297312
http://dx.doi.org/10.1186/s12863-017-0582-7

Ejemplares similares