Generation of megabase-scale deletions, inversions and duplications involving the Contactin-6 gene in mice by CRISPR/Cas9 technology

BACKGROUND: Copy Number Variation (CNV) of the human CNTN6 gene (encoding the contactin-6 protein), caused by deletions or duplications, is responsible for severe neurodevelopmental impairments, often in combination with facial dysmorphias. Conversely, deleterious point mutations of this gene do not...

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Detalles Bibliográficos
Autores principales: Korablev, Alexei N., Serova, Irina A., Serov, Oleg L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5751523/
https://www.ncbi.nlm.nih.gov/pubmed/29297312
http://dx.doi.org/10.1186/s12863-017-0582-7

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