Co-Cultured Continuously Bioluminescent Human Cells as Bioreporters for the Detection of Prodrug Therapeutic Impact Pre- and Post-Metabolism

Modern drug discovery workflows require assay systems capable of replicating the complex interactions of multiple tissue types, but that can still function under high throughput conditions. In this work, we evaluate the use of substrate-free autobioluminescence in human cell lines to support the per...

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Detalles Bibliográficos
Autores principales: Xu, Tingting, Conway, Michael, Frank, Ashley, Ripp, Steven, Sayler, Gary, Close, Dan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5751572/
https://www.ncbi.nlm.nih.gov/pubmed/29211045
http://dx.doi.org/10.3390/s17122827

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5751572/
https://www.ncbi.nlm.nih.gov/pubmed/29211045
http://dx.doi.org/10.3390/s17122827

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