Predicting effective pro-apoptotic anti-leukaemic drug combinations using co-operative dynamic BH3 profiling

The BH3-only apoptosis agonists BAD and NOXA target BCL-2 and MCL-1 respectively and co-operate to induce apoptosis. On this basis, therapeutic drugs targeting BCL-2 and MCL-1 might have enhanced activity if used in combination. We identified anti-leukaemic drugs sensitising to BCL-2 antagonism and...

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Detalles Bibliográficos
Autores principales: Grundy, Martin, Seedhouse, Claire, Jones, Thomas, Elmi, Liban, Hall, Michael, Graham, Adam, Russell, Nigel, Pallis, Monica
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5752038/
https://www.ncbi.nlm.nih.gov/pubmed/29298347
http://dx.doi.org/10.1371/journal.pone.0190682

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5752038/
https://www.ncbi.nlm.nih.gov/pubmed/29298347
http://dx.doi.org/10.1371/journal.pone.0190682

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