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Ragulator and GATOR1 complexes promote fission yeast growth by attenuating TOR complex 1 through Rag GTPases
TOR complex 1 (TORC1) is an evolutionarily conserved protein kinase complex that promotes cellular macromolecular synthesis and suppresses autophagy. Amino-acid-induced activation of mammalian TORC1 is initiated by its recruitment to the RagA/B-RagC/D GTPase heterodimer, which is anchored to lysosom...
Autores principales: | Chia, Kim Hou, Fukuda, Tomoyuki, Sofyantoro, Fajar, Matsuda, Takato, Amai, Takamitsu, Shiozaki, Kazuhiro |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5752196/ https://www.ncbi.nlm.nih.gov/pubmed/29199950 http://dx.doi.org/10.7554/eLife.30880 |
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