LRP1 regulates peroxisome biogenesis and cholesterol homeostasis in oligodendrocytes and is required for proper CNS myelin development and repair

Low-density lipoprotein receptor-related protein-1 (LRP1) is a large endocytic and signaling molecule broadly expressed by neurons and glia. In adult mice, global inducible (Lrp1(flox/flox);CAG-CreER) or oligodendrocyte (OL)-lineage specific ablation (Lrp1(flox/flox);Pdgfra-CreER) of Lrp1 attenuates...

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Detalles Bibliográficos
Autores principales: Lin, Jing-Ping, Mironova, Yevgeniya A, Shrager, Peter, Giger, Roman J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2017
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5752207/
https://www.ncbi.nlm.nih.gov/pubmed/29251594
http://dx.doi.org/10.7554/eLife.30498

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5752207/
https://www.ncbi.nlm.nih.gov/pubmed/29251594
http://dx.doi.org/10.7554/eLife.30498

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