Matrine inhibits BCR/ABL mediated ERK/MAPK pathway in human leukemia cells

The BCR/ABL fusion gene and its downstream signaling pathways such as Ras/Raf/MAPK, JAK/STAT3, and PI3K/AKT pathways play important roles in malignant transformation of leukemia, especially chronic myelogenous leukemia (CML). Our previous study showed that matrine, an alkaloid extracted from a Chine...

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Detalles Bibliográficos
Autores principales: Ma, Lingdi, Xu, Zhenyu, Wang, Jian, Zhu, Zhichao, Lin, Guibin, Jiang, Lijia, Lu, Xuzhang, Zou, Chang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5752489/
https://www.ncbi.nlm.nih.gov/pubmed/29312576
http://dx.doi.org/10.18632/oncotarget.22353

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5752489/
https://www.ncbi.nlm.nih.gov/pubmed/29312576
http://dx.doi.org/10.18632/oncotarget.22353

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