Tyrosine kinase inhibitor sensitive PDGFRΑ mutations in GIST: Two cases and review of the literature

Gastrointestinal stromal tumors (GISTs) are rare mesenchymal malignancies of the gastrointestinal tract. Most GISTs harbor a c-KIT (80%) or a PDGFRα (10%) mutation that leads to constitutive activation of the tyrosine kinase receptor. Response to treatment with tyrosine kinase inhibitors (TKIs) is d...

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Detalles Bibliográficos
Autores principales: Boonstra, Pieter A., Gietema, Jourik A., Suurmeijer, Albert J.H., Groves, Matthew R., de Assis Batista, Fernando, Schuuring, Ed, Reyners, Anna K.L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5752565/
https://www.ncbi.nlm.nih.gov/pubmed/29312652
http://dx.doi.org/10.18632/oncotarget.22663

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5752565/
https://www.ncbi.nlm.nih.gov/pubmed/29312652
http://dx.doi.org/10.18632/oncotarget.22663

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