While reinforcing cell cycle arrest, rapamycin and Torins suppress senescence in UVA-irradiated fibroblasts

Sunlight predisposes to skin cancer and melanomas. Ultraviolet A (UVA), a long wave component of sunlight, can reach dermal fibroblasts. Here we studied UVA-induced senescence in human fibroblasts in vitro. It is known that senescence occurs, when cell cycle is arrested, but mTOR is still active, th...

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Detalles Bibliográficos
Autores principales: Leontieva, Olga V., Blagosklonny, Mikhail V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5752566/
https://www.ncbi.nlm.nih.gov/pubmed/29312653
http://dx.doi.org/10.18632/oncotarget.17827

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5752566/
https://www.ncbi.nlm.nih.gov/pubmed/29312653
http://dx.doi.org/10.18632/oncotarget.17827

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