Partitioning Phenotypic Variance Due to Parent-of-Origin Effects Using Genomic Relatedness Matrices

We propose a new method, G-REMLadp, to estimate the phenotypic variance explained by parent-of-origin effects (POEs) across the genome. Our method uses restricted maximum likelihood analysis of genome-wide genetic relatedness matrices based on individuals’ phased genotypes. Genome-wide SNP data from...

Descripción completa

Detalles Bibliográficos
Autores principales: Laurin, Charles, Cuellar-Partida, Gabriel, Hemani, Gibran, Smith, George Davey, Yang, Jian, Evans, David M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2017
Materias:
Original Reasearch
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5752821/
https://www.ncbi.nlm.nih.gov/pubmed/29098496
http://dx.doi.org/10.1007/s10519-017-9880-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5752821/
https://www.ncbi.nlm.nih.gov/pubmed/29098496
http://dx.doi.org/10.1007/s10519-017-9880-0

Ejemplares similares