The Potential of a Novel Class of EPAC-Selective Agonists to Combat Cardiovascular Inflammation

The cyclic 3′,5′-adenosine monophosphate (cAMP) sensor enzyme, EPAC1, is a candidate drug target in vascular endothelial cells (VECs) due to its ability to attenuate proinflammatory cytokine signalling normally associated with cardiovascular diseases (CVDs), including atherosclerosis. This is throug...

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Detalles Bibliográficos
Autores principales: Barker, Graeme, Parnell, Euan, van Basten, Boy, Buist, Hanna, Adams, David R., Yarwood, Stephen J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5753123/
https://www.ncbi.nlm.nih.gov/pubmed/29367551
http://dx.doi.org/10.3390/jcdd4040022

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5753123/
https://www.ncbi.nlm.nih.gov/pubmed/29367551
http://dx.doi.org/10.3390/jcdd4040022

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