Recent progress in the racemic and enantioselective synthesis of monofluoroalkene-based dipeptide isosteres

Monofluoroalkenes are fluorinated motifs that can be used to replace amide bonds. In order to be incorporated into peptides, it is normally necessary to first synthesize a dipeptide where the amide bond has been replaced with a monofluoroalkene. In that context, this review will present the racemic...

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Detalles Bibliográficos
Autores principales: Drouin, Myriam, Paquin, Jean-François
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Beilstein-Institut 2017
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5753175/
https://www.ncbi.nlm.nih.gov/pubmed/29564002
http://dx.doi.org/10.3762/bjoc.13.262
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author Drouin, Myriam
Paquin, Jean-François
author_facet Drouin, Myriam
Paquin, Jean-François
author_sort Drouin, Myriam
collection PubMed
description Monofluoroalkenes are fluorinated motifs that can be used to replace amide bonds. In order to be incorporated into peptides, it is normally necessary to first synthesize a dipeptide where the amide bond has been replaced with a monofluoroalkene. In that context, this review will present the racemic and enantioselective synthesis of monofluoroalkene-based dipeptide isosteres described since 2007. Some applications of those compounds will also be presented.
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spelling pubmed-57531752018-03-21 Recent progress in the racemic and enantioselective synthesis of monofluoroalkene-based dipeptide isosteres Drouin, Myriam Paquin, Jean-François Beilstein J Org Chem Review Monofluoroalkenes are fluorinated motifs that can be used to replace amide bonds. In order to be incorporated into peptides, it is normally necessary to first synthesize a dipeptide where the amide bond has been replaced with a monofluoroalkene. In that context, this review will present the racemic and enantioselective synthesis of monofluoroalkene-based dipeptide isosteres described since 2007. Some applications of those compounds will also be presented. Beilstein-Institut 2017-12-12 /pmc/articles/PMC5753175/ /pubmed/29564002 http://dx.doi.org/10.3762/bjoc.13.262 Text en Copyright © 2017, Drouin and Paquin https://creativecommons.org/licenses/by/4.0https://www.beilstein-journals.org/bjoc/termsThis is an Open Access article under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The license is subject to the Beilstein Journal of Organic Chemistry terms and conditions: (https://www.beilstein-journals.org/bjoc/terms)
spellingShingle Review
Drouin, Myriam
Paquin, Jean-François
Recent progress in the racemic and enantioselective synthesis of monofluoroalkene-based dipeptide isosteres
title Recent progress in the racemic and enantioselective synthesis of monofluoroalkene-based dipeptide isosteres
title_full Recent progress in the racemic and enantioselective synthesis of monofluoroalkene-based dipeptide isosteres
title_fullStr Recent progress in the racemic and enantioselective synthesis of monofluoroalkene-based dipeptide isosteres
title_full_unstemmed Recent progress in the racemic and enantioselective synthesis of monofluoroalkene-based dipeptide isosteres
title_short Recent progress in the racemic and enantioselective synthesis of monofluoroalkene-based dipeptide isosteres
title_sort recent progress in the racemic and enantioselective synthesis of monofluoroalkene-based dipeptide isosteres
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5753175/
https://www.ncbi.nlm.nih.gov/pubmed/29564002
http://dx.doi.org/10.3762/bjoc.13.262
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