Sodium Valproate, a Histone Deacetylase Inhibitor, Is Associated With Reduced Stroke Risk After Previous Ischemic Stroke or Transient Ischemic Attack

BACKGROUND AND PURPOSE—: A variant in the histone deacetylase 9 (HDAC9) gene is associated with large artery stroke. Therefore, inhibiting HDAC9 might offer a novel secondary preventative treatment for ischemic stroke. The antiepileptic drug sodium valproate (SVA) is a nonspecific inhibitor of HDAC9...

Descripción completa

Detalles Bibliográficos
Autores principales: Brookes, Rebecca L., Crichton, Siobhan, Wolfe, Charles D.A., Yi, Qilong, Li, Linxin, Hankey, Graeme J., Rothwell, Peter M., Markus, Hugh S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2018
Materias:
Original Contributions
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5753817/
https://www.ncbi.nlm.nih.gov/pubmed/29247141
http://dx.doi.org/10.1161/STROKEAHA.117.016674

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5753817/
https://www.ncbi.nlm.nih.gov/pubmed/29247141
http://dx.doi.org/10.1161/STROKEAHA.117.016674

Ejemplares similares