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Sodium Valproate, a Histone Deacetylase Inhibitor, Is Associated With Reduced Stroke Risk After Previous Ischemic Stroke or Transient Ischemic Attack

BACKGROUND AND PURPOSE—: A variant in the histone deacetylase 9 (HDAC9) gene is associated with large artery stroke. Therefore, inhibiting HDAC9 might offer a novel secondary preventative treatment for ischemic stroke. The antiepileptic drug sodium valproate (SVA) is a nonspecific inhibitor of HDAC9...

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Detalles Bibliográficos
Autores principales:	Brookes, Rebecca L., Crichton, Siobhan, Wolfe, Charles D.A., Yi, Qilong, Li, Linxin, Hankey, Graeme J., Rothwell, Peter M., Markus, Hugh S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Lippincott Williams & Wilkins 2018
Materias:	Original Contributions
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5753817/ https://www.ncbi.nlm.nih.gov/pubmed/29247141 http://dx.doi.org/10.1161/STROKEAHA.117.016674

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