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Blocking the VISTA pathway enhances disease progression in (NZB × NZW) F1 female mice
V-domain Ig suppressor of T-cell activation (VISTA) is a critical negative checkpoint molecule involved in regulating the immune response. Targeting the pathway with an antagonist anti-VISTA antibody designated 13F3 has been shown to enhance disease severity in experimental autoimmune encephalomyeli...
Autores principales: | Sergent, PA, Plummer, SF, Pettus, J, Mabaera, R, DeLong, JK, Pechenick, DA, Burns, CM, Noelle, RJ, Ceeraz, S |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5753845/ https://www.ncbi.nlm.nih.gov/pubmed/28659048 http://dx.doi.org/10.1177/0961203317716322 |
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