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The Evolution of Gene-Specific Transcriptional Noise Is Driven by Selection at the Pathway Level

Biochemical reactions within individual cells result from the interactions of molecules, typically in small numbers. Consequently, the inherent stochasticity of binding and diffusion processes generates noise along the cascade that leads to the synthesis of a protein from its encoding gene. As a res...

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Detalles Bibliográficos
Autores principales: Barroso, Gustavo Valadares, Puzovic, Natasa, Dutheil, Julien Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Genetics Society of America 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5753856/
https://www.ncbi.nlm.nih.gov/pubmed/29097405
http://dx.doi.org/10.1534/genetics.117.300467