Higher Nevus Count Exhibits a Distinct DNA Methylation Signature in Healthy Human Skin: Implications for Melanoma

High nevus count is the strongest risk factor for melanoma, and although gene variants have been discovered for both traits, epigenetic variation is unexplored. We investigated 322 healthy human skin DNA methylomes associated with total body nevi count, incorporating genetic and transcriptomic varia...

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Detalles Bibliográficos
Autores principales: Roos, Leonie, Sandling, Johanna K., Bell, Christopher G., Glass, Daniel, Mangino, Massimo, Spector, Tim D., Deloukas, Panos, Bataille, Veronique, Bell, Jordana T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5754330/
https://www.ncbi.nlm.nih.gov/pubmed/27993549
http://dx.doi.org/10.1016/j.jid.2016.11.029

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5754330/
https://www.ncbi.nlm.nih.gov/pubmed/27993549
http://dx.doi.org/10.1016/j.jid.2016.11.029

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