Trithorax dependent changes in chromatin landscape at enhancer and promoter regions drive female puberty

Polycomb group (PcG) proteins control the timing of puberty by repressing the Kiss1 gene in hypothalamic arcuate nucleus (ARC) neurons. Here we identify two members of the Trithorax group (TrxG) of modifiers, mixed-lineage leukemia 1 (MLL1), and 3 (MLL3), as central components of an activating epige...

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Detalles Bibliográficos
Autores principales: Toro, Carlos A., Wright, Hollis, Aylwin, Carlos F., Ojeda, Sergio R., Lomniczi, Alejandro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5754362/
https://www.ncbi.nlm.nih.gov/pubmed/29302059
http://dx.doi.org/10.1038/s41467-017-02512-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5754362/
https://www.ncbi.nlm.nih.gov/pubmed/29302059
http://dx.doi.org/10.1038/s41467-017-02512-1

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