Loss of mtDNA activates astrocytes and leads to spongiotic encephalopathy

Mitochondrial dysfunction manifests as different neurological diseases, but the mechanisms underlying the clinical variability remain poorly understood. To clarify whether different brain cells have differential sensitivity to mitochondrial dysfunction, we induced mitochondrial DNA (mtDNA) depletion...

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Detalles Bibliográficos
Autores principales: Ignatenko, Olesia, Chilov, Dmitri, Paetau, Ilse, de Miguel, Elena, Jackson, Christopher B., Capin, Gabrielle, Paetau, Anders, Terzioglu, Mugen, Euro, Liliya, Suomalainen, Anu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5754366/
https://www.ncbi.nlm.nih.gov/pubmed/29302033
http://dx.doi.org/10.1038/s41467-017-01859-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5754366/
https://www.ncbi.nlm.nih.gov/pubmed/29302033
http://dx.doi.org/10.1038/s41467-017-01859-9

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