C9ORF72 GGGGCC repeat-associated non-AUG translation is upregulated by stress through eIF2α phosphorylation

Hexanucleotide repeat expansion in C9ORF72 is the most frequent cause of both amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Here we demonstrate that the repeat-associated non-AUG (RAN) translation of (GGGGCC)(n)-containing RNAs into poly-dipeptides can initiate in vivo witho...

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Detalles Bibliográficos
Autores principales: Cheng, Weiwei, Wang, Shaopeng, Mestre, Alexander A., Fu, Chenglai, Makarem, Andres, Xian, Fengfan, Hayes, Lindsey R., Lopez-Gonzalez, Rodrigo, Drenner, Kevin, Jiang, Jie, Cleveland, Don W., Sun, Shuying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5754368/
https://www.ncbi.nlm.nih.gov/pubmed/29302060
http://dx.doi.org/10.1038/s41467-017-02495-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5754368/
https://www.ncbi.nlm.nih.gov/pubmed/29302060
http://dx.doi.org/10.1038/s41467-017-02495-z

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