Mass balance, metabolic disposition, and pharmacokinetics of a single oral dose of regorafenib in healthy human subjects

PURPOSE: To evaluate the mass balance, metabolic disposition, and pharmacokinetics of a single dose of regorafenib in healthy volunteers. In addition, in vitro metabolism of regorafenib in human hepatocytes was investigated. METHODS: Four healthy male subjects received one 120 mg oral dose of regora...

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Detalles Bibliográficos
Autores principales: Gerisch, Michael, Hafner, Frank-Thorsten, Lang, Dieter, Radtke, Martin, Diefenbach, Konstanze, Cleton, Adriaan, Lettieri, John
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5754413/
https://www.ncbi.nlm.nih.gov/pubmed/29188322
http://dx.doi.org/10.1007/s00280-017-3480-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5754413/
https://www.ncbi.nlm.nih.gov/pubmed/29188322
http://dx.doi.org/10.1007/s00280-017-3480-9

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