Kras mutant genetically engineered mouse models of human cancers are genomically heterogeneous

KRAS mutant tumors are largely recalcitrant to targeted therapies. Genetically engineered mouse models (GEMMs) of Kras mutant cancer recapitulate critical aspects of this disease and are widely used for preclinical validation of targets and therapies. Through comprehensive profiling of exomes and ma...

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Detalles Bibliográficos
Autores principales: Chung, Wei-Jen, Daemen, Anneleen, Cheng, Jason H., Long, Jason E., Cooper, Jonathan E., Wang, Bu-er, Tran, Christopher, Singh, Mallika, Gnad, Florian, Modrusan, Zora, Foreman, Oded, Junttila, Melissa R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2017
Materias:
PNAS Plus
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5754767/
https://www.ncbi.nlm.nih.gov/pubmed/29203670
http://dx.doi.org/10.1073/pnas.1708391114

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5754767/
https://www.ncbi.nlm.nih.gov/pubmed/29203670
http://dx.doi.org/10.1073/pnas.1708391114

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