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Development and validation of a high-throughput transcriptomic biomarker to address 21st century genetic toxicology needs
Interpretation of positive genotoxicity findings using the current in vitro testing battery is a major challenge to industry and regulatory agencies. These tests, especially mammalian cell assays, have high sensitivity but suffer from low specificity, leading to high rates of irrelevant positive fin...
| Autores principales: | , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
National Academy of Sciences
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5754797/ https://www.ncbi.nlm.nih.gov/pubmed/29203651 http://dx.doi.org/10.1073/pnas.1714109114 |