Investigation of in vitro absorption, distribution, metabolism, and excretion and in vivo pharmacokinetics of paromomycin: Influence on oral bioavailability

OBJECTIVE: The objective of this study is to investigate in vitro Caco2 permeability, metabolism and in vivo pharmacokinetic (PK) properties of paromomycin to develop an efficient dosage form with improved oral bioavailability. MATERIALS AND METHODS: For the purpose, Caco2 permeability assay, mouse...

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Detalles Bibliográficos
Autores principales: K. Pinjari, M. Jakir S., Somani, Rahul, Gilhotra, Ritu M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5754937/
https://www.ncbi.nlm.nih.gov/pubmed/29326490
http://dx.doi.org/10.4103/ijp.IJP_651_16

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5754937/
https://www.ncbi.nlm.nih.gov/pubmed/29326490
http://dx.doi.org/10.4103/ijp.IJP_651_16

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