Combined inhibition of BET proteins and class I HDACs synergistically induces apoptosis in urothelial carcinoma cell lines

BACKGROUND: New efficient therapies for urothelial carcinoma (UC) are urgently required. Small-molecule drugs targeting chromatin regulators are reasonable candidates because these regulators are frequently mutated or deregulated in UC. Indeed, in previous work, Romidepsin, which targets class I his...

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Detalles Bibliográficos
Autores principales: Hölscher, Alexander S., Schulz, Wolfgang A., Pinkerneil, Maria, Niegisch, Günter, Hoffmann, Michèle J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5755363/
https://www.ncbi.nlm.nih.gov/pubmed/29312470
http://dx.doi.org/10.1186/s13148-017-0434-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5755363/
https://www.ncbi.nlm.nih.gov/pubmed/29312470
http://dx.doi.org/10.1186/s13148-017-0434-3

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