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Active-site solvent replenishment observed during human carbonic anhydrase II catalysis
Human carbonic anhydrase II (hCA II) is a zinc metalloenzyme that catalyzes the reversible hydration/dehydration of CO(2)/HCO(3) (−). Although hCA II has been extensively studied to investigate the proton-transfer process that occurs in the active site, its underlying mechanism is still not fully un...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
International Union of Crystallography
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5755581/ https://www.ncbi.nlm.nih.gov/pubmed/29354275 http://dx.doi.org/10.1107/S2052252517017626 |