Enhanced MYC association with the NuA4 histone acetyltransferase complex mediated by the adenovirus E1A N-terminal domain activates a subset of MYC target genes highly expressed in cancer cells

The proto-oncogene MYC is a transcription factor over-expressed in many cancers and required for cell survival. Its function is regulated by histone acetyltransferase (HAT) complexes, such as the GCN5 complex and the NuA4/Tip60 complex. However, the roles of the HAT complexes during MYC function in...

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Detalles Bibliográficos
Autores principales: Zhao, Ling-Jun, Loewenstein, Paul M., Green, Maurice
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5755721/
https://www.ncbi.nlm.nih.gov/pubmed/29321817
http://dx.doi.org/10.18632/genesandcancer.160

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5755721/
https://www.ncbi.nlm.nih.gov/pubmed/29321817
http://dx.doi.org/10.18632/genesandcancer.160

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