Cargando…

EWS-FLI-1 creates a cell surface microenvironment conducive to IGF signaling by inducing pappalysin-1

Ewing sarcoma is an aggressive cancer of bone and soft tissue in children with poor prognosis. It is characterized by the chromosomal translocation between EWS and an Ets family transcription factor, most commonly FLI-1. EWS-FLI-1 fusion accounts for 85% of Ewing sarcoma cases. EWS-FLI-1 regulates t...

Descripción completa

Detalles Bibliográficos
Autores principales: Jayabal, Panneerselvam, Houghton, Peter J., Shiio, Yuzuru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5755722/
https://www.ncbi.nlm.nih.gov/pubmed/29321818
http://dx.doi.org/10.18632/genesandcancer.159