Discovery of indolylpiperazinylpyrimidines with dual-target profiles at adenosine A(2A) and dopamine D(2) receptors for Parkinson's disease treatment

Parkinson’s disease (PD) is a neurodegenerative disorder characterized by progressive loss of dopaminergic neurons in the substantia nigra of the human brain, leading to depletion of dopamine production. Dopamine replacement therapy remains the mainstay for attenuation of PD symptoms. Nonetheless, t...

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Detalles Bibliográficos
Autores principales: Shao, Yi-Ming, Ma, Xiaohua, Paira, Priyankar, Tan, Aaron, Herr, Deron Raymond, Lim, Kah Leong, Ng, Chee Hoe, Venkatesan, Gopalakrishnan, Klotz, Karl-Norbert, Federico, Stephanie, Spalluto, Giampiero, Cheong, Siew Lee, Chen, Yu Zong, Pastorin, Giorgia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5755735/
https://www.ncbi.nlm.nih.gov/pubmed/29304113
http://dx.doi.org/10.1371/journal.pone.0188212

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5755735/
https://www.ncbi.nlm.nih.gov/pubmed/29304113
http://dx.doi.org/10.1371/journal.pone.0188212

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