The sorafenib anti-relapse effect after alloHSCT is associated with heightened alloreactivity and accumulation of CD8+PD-1+ (CD279+) lymphocytes in marrow

We studied three FLT3 ITD acute myeloid leukemia (AML) patients who relapsed after allogeneic haematopoietic stem cell transplantation (alloHSCT) and received multikinase inhibitor (MKI) sorafenib as part of salvage therapy. MKI was given to block the effect of FLT3 ITD mutation which powers prolife...

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Detalles Bibliográficos
Autores principales: Lange, Andrzej, Jaskula, Emilia, Lange, Janusz, Dworacki, Grzegorz, Nowak, Dorota, Simiczyjew, Aleksandra, Mordak-Domagala, Monika, Sedzimirska, Mariola
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5755786/
https://www.ncbi.nlm.nih.gov/pubmed/29304116
http://dx.doi.org/10.1371/journal.pone.0190525

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5755786/
https://www.ncbi.nlm.nih.gov/pubmed/29304116
http://dx.doi.org/10.1371/journal.pone.0190525

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