Genome scale metabolic models as tools for drug design and personalized medicine

In this work we aim to show how Genome Scale Metabolic Models (GSMMs) can be used as tools for drug design. By comparing the chemical structures of human metabolites (obtained using their KEGG indexes) and the compounds contained in the DrugBank database, we have observed that compounds showing Tani...

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Detalles Bibliográficos
Autores principales: Raškevičius, Vytautas, Mikalayeva, Valeryia, Antanavičiūtė, Ieva, Ceslevičienė, Ieva, Skeberdis, Vytenis Arvydas, Kairys, Visvaldas, Bordel, Sergio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5755790/
https://www.ncbi.nlm.nih.gov/pubmed/29304175
http://dx.doi.org/10.1371/journal.pone.0190636

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5755790/
https://www.ncbi.nlm.nih.gov/pubmed/29304175
http://dx.doi.org/10.1371/journal.pone.0190636

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