Unlinking the methylome pattern from nucleotide sequence, revealed by large-scale in vivo genome engineering and methylome editing in medaka fish

The heavily methylated vertebrate genomes are punctuated by stretches of poorly methylated DNA sequences that usually mark gene regulatory regions. It is known that the methylation state of these regions confers transcriptional control over their associated genes. Given its governance on the transcr...

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Detalles Bibliográficos
Autores principales: Cheung, Napo K. M., Nakamura, Ryohei, Uno, Ayako, Kumagai, Masahiko, Fukushima, Hiroto S., Morishita, Shinichi, Takeda, Hiroyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5755920/
https://www.ncbi.nlm.nih.gov/pubmed/29267279
http://dx.doi.org/10.1371/journal.pgen.1007123

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5755920/
https://www.ncbi.nlm.nih.gov/pubmed/29267279
http://dx.doi.org/10.1371/journal.pgen.1007123

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