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In vitro FRET analysis of IRE1 and BiP association and dissociation upon endoplasmic reticulum stress

The unfolded protein response (UPR) is a key signaling system that regulates protein homeostasis within the endoplasmic reticulum (ER). The primary step in UPR activation is the detection of misfolded proteins, the mechanism of which is unclear. We have previously suggested an allosteric mechanism f...

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Detalles Bibliográficos
Autores principales: Kopp, Megan C, Nowak, Piotr R, Larburu, Natacha, Adams, Christopher J, Ali, Maruf MU
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5756023/
https://www.ncbi.nlm.nih.gov/pubmed/29303481
http://dx.doi.org/10.7554/eLife.30257