Pooled screening for anti-proliferative inhibitors of protein-protein interactions

Protein-protein interactions (PPIs) are emerging as a promising new class of drug targets. Here, we present a novel high-throughput approach to screen inhibitors of PPIs in cells. We designed a library of 50,000 human peptide binding motifs and used a pooled lentiviral system to express them intrace...

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Detalles Bibliográficos
Autores principales: Nim, Satra, Jeon, Jouhyun, Corbi-Verge, Carles, Seo, Moon-Hyeong, Ivarsson, Ylva, Moffat, Jason, Tarasova, Nadya, Kim, Philip M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5756068/
https://www.ncbi.nlm.nih.gov/pubmed/26900867
http://dx.doi.org/10.1038/nchembio.2026

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5756068/
https://www.ncbi.nlm.nih.gov/pubmed/26900867
http://dx.doi.org/10.1038/nchembio.2026

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