Targeting mitochondrial translation by inhibiting DDX3: a novel radiosensitization strategy for cancer treatment

DDX3 is a DEAD box RNA helicase with oncogenic properties. RK-33 is developed as a small molecule inhibitor of DDX3 and showed potent radiosensitizing activity in preclinical tumor models. This study aimed to assess DDX3 as a target in breast cancer and to elucidate how RK-33 exerts its anti-neoplas...

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Detalles Bibliográficos
Autores principales: Heerma van Voss, Marise R., Vesuna, Farhad, Bol, Guus M., Afzal, Junaid, Tantravedi, Saritha, Bergman, Yehudit, Kammers, Kai, Lehar, Mohamed, Malek, Reem, Ballew, Matthew, ter Hoeve, Natalie, Abou, Diane, Thorek, Daniel, Berlinicke, Cynthia, Yazdankhah, Meysam, Sinha, Debasish, Le, Anne, Abrahams, Roselle, Tran, Phuoc T., van Diest, Paul J., Raman, Venu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5756132/
https://www.ncbi.nlm.nih.gov/pubmed/28869602
http://dx.doi.org/10.1038/onc.2017.308

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5756132/
https://www.ncbi.nlm.nih.gov/pubmed/28869602
http://dx.doi.org/10.1038/onc.2017.308

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