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Generation and characterization of tissue-type plasminogen activator transgenic rats

To address a species difference in the responsiveness to human recombinant tissue-type plasminogen activator (rt-PA) between rats and humans, tPA transgenic (Tg) rats were generated and characterized. In the rats, transcriptional regulation of tPA was designed under the control of the endogenous tPA...

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Detalles Bibliográficos
Autores principales: Ito, Yusuke, Noguchi, Kengo, Morishima, Yoshiyuki, Yamaguchi, Kyoji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5756269/
https://www.ncbi.nlm.nih.gov/pubmed/29168147
http://dx.doi.org/10.1007/s11239-017-1582-1