A phase 1 evaluation of the pharmacokinetic/pharmacodynamic interaction of the anti-malarial agents KAF156 and piperaquine

BACKGROUND: KAF156 is a novel imidazolopiperazine anti-malarial with activity against pre-erythrocytic liver stages, asexual and sexual blood stages. Based on in vitro data, a two-way pharmacokinetic interaction was hypothesized for KAF156 use in combination with piperaquine (PPQ) as both drugs are...

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Detalles Bibliográficos
Autores principales: Leong, F. Joel, Jain, Jay Prakash, Feng, Yiyan, Goswami, Budhaditya, Stein, Daniel S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5756412/
https://www.ncbi.nlm.nih.gov/pubmed/29304859
http://dx.doi.org/10.1186/s12936-017-2162-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5756412/
https://www.ncbi.nlm.nih.gov/pubmed/29304859
http://dx.doi.org/10.1186/s12936-017-2162-8

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