The generation of a simian adenoviral vectored HCV vaccine encoding genetically conserved gene segments to target multiple HCV genotypes

BACKGROUND: Hepatitis C virus (HCV) genomic variability is a major challenge to the generation of a prophylactic vaccine. We have previously shown that HCV specific T-cell responses induced by a potent T-cell vaccine encoding a single strain subtype-1b immunogen target epitopes dominant in natural i...

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Detalles Bibliográficos
Autores principales: von Delft, Annette, Donnison, Timothy A., Lourenço, José, Hutchings, Claire, Mullarkey, Caitlin E., Brown, Anthony, Pybus, Oliver G., Klenerman, Paul, Chinnakannan, Senthil, Barnes, Eleanor
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Science 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5756538/
https://www.ncbi.nlm.nih.gov/pubmed/29203182
http://dx.doi.org/10.1016/j.vaccine.2017.10.079

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5756538/
https://www.ncbi.nlm.nih.gov/pubmed/29203182
http://dx.doi.org/10.1016/j.vaccine.2017.10.079

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