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Introduction of H2C2‐type zinc‐binding residues into HIV‐2 Vpr increases its expression level

Human immunodeficiency virus type 2 has two structurally similar proteins, Vpx and Vpr. Vpx degrades the host anti‐viral protein SAMHD1 and is expressed at high levels, while Vpr is responsible for cell cycle arrest and is expressed at much lower levels. We constructed a Vpr mutant with a high level...

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Detalles Bibliográficos
Autores principales: Koga, Ryoko, Yamamoto, Minami, Ciftci, Halil Ibrahim, Otsuka, Masami, Fujita, Mikako
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5757179/
https://www.ncbi.nlm.nih.gov/pubmed/29321964
http://dx.doi.org/10.1002/2211-5463.12358